Frank Alber, Ph.D.
Molecular & Computational Biology, Department of Biological Sciences
University of Southern California, 1050 Childs Way, RRI413E, Los Angeles, CA 90089
Phone: +1 (213) 740 0778, Fax: +1 (213) 740 2437, email: alber at
Curriculum Vitae (pdf)

Ph.D.: ETH Zurich, Switzerland
Visiting Scientist: IBM Research Laboratory, Rueschlikon, Switzerland
MS. (Dipl. Chem.): University of Tuebingen, Germany

Postdoctoral research at:
SISSA Trieste, Italy (Carloni Lab)
Rockefeller University (Sali lab) and University of California San Francisco (Sali lab)

Awards and Honors:
2009 Alfred P. Sloan Research fellow
2009 PEW Scholar in the Biomedical Sciences.
2011 Selected as Kavli Frontiers of Science Fellow
2012 NSF CAREER. Faculty Early Career Development Award.
2012 Beckman Young Investigator Award (BYI)

Research Interests:
Computational Structural Biology, Structural Cell Biology, Nuclear Architecture, Genome Organization, Structure and Function of the Nuclear Pore Complex, Structure Determination of Proteins and Large Assemblies, Cryo-electron Microscopy/Tomography, Image Analysis and Pattern Recognition.

Selected Pu

3D Genome Organization:

H. Tjong, W. Li, R. Kalhor, K. Gong, C. Dai, H. Li, X.J. Zhou, LeGros M., C. Larabell, L. Chen, F. Alber (2016)
Population–based 3D genome structure analysis reveals driving forces in spatial genome organization.
Proc. Natl. Acad. Sc. USA, 113 (12), E1665. (pdf)
doi: 10.1073/pnas.1512577113.
(Suppl. Materials)

C. Dai, W. Li, H. Tjong, S. Hao, Y. Zhou, Q. Li, L. Chen, B. Zhu, F. Alber, X.J. Zhou (2016)
Population analysis of 3D genome structures reveals major factors governing the stability of regulatory communities
Nature Communications, 7, 11549. (pdf)

H. Tjong, K. Gong, L. Chen, F. Alber (2012)
Physical tethering and volume exclusion determine higher order genome organization in budding yeast.
Genome Research, 22 (7), 1295-1305. (pdf).

R. Kalhor, H. Tjong, N. Jayathilaka, F. Alber L. Chen (2011)
Genome architectures revealed by tethered chromosome conformation capture and population-based modeling.
Nature Biotechnology, 30(1), 90-98. (pdf)

Visual Proteomics:

M. Xu, M. Beck, F. Alber (2011)
Template-free detection of macromolecular complexes in cryo-electron tomograms.
Bioinformatics (ISMB), 27(13):i69-i76. (pdf)

M. Xu, M. Beck, F. Alber (2012)
High-throughput subtomogram alignment and classification by Fourier space constrained volumetric matching.
Journal of Structural Biology, 178(2):152-64. (pdf)

Nuclear Pore Complex:

F. Alber, S. Dokudovskaya, L. Veenhoff, W. Zhang, J. Kipper, D. Devos, A. Suprapto, O. Karni-Schmidt, R. Williams, B.T. Chait, A. Sali, M.P. Rout. (2007)
The Molecular Architecture of the Nuclear Pore Complex.
Nature, 450: 695-701. (pdf)

F. Alber, S. Dokudovskaya, L. Veenhoff, W. Zhang, J. Kipper, D. Devos, A. Suprapto, O. Karni-Schmidt, R. Williams, B.T. Chait, M.P. Rout, A. Sali. (2007)
Determining the Architectures of Macromolecular Assemblies.
e, 450: 683-694. (pdf)

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